Table II.
Effect of repeated inhalation of sevoflurane on the movement behavior of GABAA R ε knockout and wild-type neonatal mice.
Group | Coordination of right rear to left front | Ipsilateral coordination of right front to left front | Swing phase-left front, sec | Swing phase-right front, sec | Support phase-left front, sec | Support phase-right front, sec | Propulsion index of left rear | Propulsion index of left front | Braking index of left rear | Average area of right rear footprint, mm2 |
---|---|---|---|---|---|---|---|---|---|---|
Control, n=20 | 0.547±0.092 | 0.552±0.093 | 0.633±0.114 | 0.636±0.113 | 0.323±0.077 | 0.337±0.064 | 0.804±0.121 | 0.563±0.076 | 0.226±0.032 | 2.512±0.375 |
GABAA-R ε knockout mice | ||||||||||
12 days, n=20 | 0.536±0.093 | 0.549±0.073 | 0.634±0.079 | 0.632±0.095 | 0.331±0.064 | 0.341±0.059 | 0.796±0.114 | 0.559±0.067 | 0.224±0.074 | 2.449±0.483 |
24 days, n=20 | 0.521±0.115 | 0.533±0.069 | 0.618±0.093 | 0.619±0.075 | 0.329±0.084 | 0.339±0.067 | 0.785±0.097 | 0.562±0.089 | 0.231±0.043 | 2.593±0.618 |
Wild-type mice | ||||||||||
12 days, n=20 | 0.378±0.063a | 0.395±0.104a | 0.479±0.062a | 0.442±0.095a | 0.463±0.085a | 0.483±0.067a | 0.615±0.078a | 0.416±0.074a | 0.368±0.074a | 6.114±0.817a |
24 days, n=20 | 0.283±0.062a | 0.257±0.053a | 0.341±0.057a | 0.273±0.053a | 0.569±0.107a | 0.668±0.093a | 0.463±0.057a | 0.268±0.028a | 0.485±0.075a | 9.634±0.829a |
P<0.05 vs. control. GABAA-R ε, γ-aminobutyric acidA receptor ε subunit.