Table I.
Effect of chronic scopolamine treatment on the Morris water maze test.
| Training escape latency (sec) | Test escape latency (sec) | |||
|---|---|---|---|---|
| Group | Day 1 | Day 2 | Day 3 | Day 4 |
| Control | ||||
| 0 weeks | 68.2±5.5 | 60.4±4.2 | 49.8±5.8 | 43.6±7.9 |
| 1 week | 66.3±3.9 | 59.2±3.2 | 46.3±4.2 | 41.2±6.2 |
| 2 weeks | 69.8±4.7 | 61.6±3.9 | 45.2±5.5 | 39.8±7.1 |
| 3 weeks | 64.1±4.6 | 57.7±8.1 | 42.6±3.1 | 35.5±8.0 |
| 4 weeks | 67.5±5.2 | 54.4±3.9 | 43.5±6.2 | 33.4±9.1 |
| SCO | ||||
| 0 weeks | 65.7±3.5 | 55.7±4.1 | 44.6±5.5 | 40.1±8.2 |
| 1 week | 77.4±5.7a | 78.5±7.3a | 76.5±8.2a | 79.3±9.0a |
| 2 weeks | 73.5±6.3a | 75.2±5.9a | 74.9±7.8a | 75.7±10.3a |
| 3 weeks | 79.6±7.2a | 77.4±6.2a | 75.7±6.8a | 77.9±7.4a |
| 4 weeks | 80.2±9.3a | 81.8±6.6a | 77.4±5.7a | 75.8±9.2a |
Escape latency time in seconds in the control and SCO-treated groups during training and test periods (n=7/group).
a
P<0.05 vs. control group. SCO, scopolamine.