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. 2017 Nov 15;17(1):1753–1761. doi: 10.3892/mmr.2017.8081

Figure 4.

Figure 4.

Effect of prehypertensive losartan therapy on the methylation level of the AT1aR, AT1bR and ATRAP promoters in the adipose tissue of high-fat-fed SHRs at 26 weeks of age. (A) CpG sites of AT1aR gene promoter as the targets of methylation status analysis, (B) methylation level of AT1aR gene promoter, (C) CpG sites of AT1bR gene promoter as the targets of methylation status analysis, (D) methylation level of AT1bR gene promoter, (E) CpG sites of ATRAP gene promoter as the targets of methylation status analysis. (F) Methylation level of ATRAP gene promoter. *P<0.05 vs. SC; #P<0.05 vs. HF. The data are represented as the mean ± standard deviation. n=8. AT1aR, angiotensin II type 1 receptor subtype a; ATRAP, AT1R-associated protein; SHRs, spontaneously hypertensive rats; SC, standard chow-fed SHRs; HF, high-fat-fed SHRs; SC-Los, losartan-treated SHRs on standard chow; HF-Los, losartan-treated SHRs on high-fat diet.