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. 2017 Nov 15;17(1):1762–1774. doi: 10.3892/mmr.2017.8068

Figure 4.

Figure 4.

IBTX did not alter the majority of burst and ABH parameters, with the exception of burst duration. (A-C) Representative original traces with and without 500 nM IBTX in the DMSO control and 5 µM CTZ groups for 2 h. The boxes indicate the area that has been enlarged in the subsequent images. No statistical difference was identified between groups treated with and without IBTX in terms of (D) ABH amplitude, (E) ABH duration, (F) bursting neuron percentage [the numbers written in the bars represent the number of cells (number with burst activities/total number)], (G) bursting number per minute and (H) AP frequency in burst, in the control (n=47 bursts in 11 neurons without IBTX; n=22 bursts in 5 neurons with IBTX) and CTZ groups (n=35 bursts in 10 neurons without IBTX; n=23 bursts in 5 neurons with IBTX). (I) IBTX significantly increased the burst duration in the two groups. Data are presented as the mean ± standard error mean. *P<0.05 DMSO vs. DMSO + IBTX; ###P<0.001 CTZ vs. CTZ + IBTX. IBTX, iberiotoxin; ABH, after burst hyperpolarization; CTZ, cyclothiazide; AP, action potential.