Table I.
Treatment 1 | Treatment 2 | |||
---|---|---|---|---|
Group | Reagent | Description | Reagent | Description |
Ctrl | Physiological saline | 10 days prior to injection; oral administration; equal volume to matrine | Sodium citrate buffer (pH 4.5) | Equal volume to STZ injection; single intraperitoneal injection |
DbCM | Physiological saline | 10 days before injection; oral administration; equal volume to matrine | STZ (dissolved in sodium citrate buffer, pH 4.5) | 65 mg/kg body weight; single intraperitoneal injection |
Mat | Matrine | 10 days before injection; oral administration; 200 mg/kg/day for 10 consecutive days | Sodium citrate buffer, pH 4.5 | Equal volume to STZ injection; single intraperitoneal injection |
DbCM+Mat | Matrine | 10 days prior to injection; oral administration; 200 mg/kg/day for 10 consecutive days | STZ (dissolved in sodium citrate buffer with pH 4.5) | 65 mg/kg body weight; single intraperitoneal injection |
Ctrl, control; Mat, matrine; STZ, streptozotocin; DbCM, diabetic cardiomyopathy.