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. 2017 Oct 26;17(1):234–242. doi: 10.3892/mmr.2017.7909

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — CRF-R1 expression level was increased in the colon samples of the DSS-treated mice. (A) Expression level of CRF-R1 mRNA in the colon samples from the DSS-treated mice increased as the number of days of DSS treatment increased. The ip injections of 10 mg/kg CP154526 (n=8) significantly decreased the CRF-R1 (B) mRNA and (C and D) protein expression levels in the colon samples from the DSS-treated mice. However, the ip injections of 30 µg/kg CRF (n=7) did not alter the expression level of CRF-R1. ^#P<0.05 vs. the DSS-treated mice on day 0. *P<0.05 vs. saline + DSS group. CRF, corticotropin-releasing factor; CRF-R1, corticotropin-releasing factor receptor 1; DSS, dextran sulphate sodium.