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. 2017 Oct 26;17(1):234–242. doi: 10.3892/mmr.2017.7909

Figure 2.

Figure 2.

Effect of CRF-R1 on DSS-induced colitis. The ip injection of CRF aggravated DSS-induced colitis, (A) exhibited by increased mucosa oedema, ulcerations and infiltration of inflammatory cells (magnification, ×100), (B) evaluated by histopathological score and (C) shortened colon. By contrast, the ip injection of CP154526 alleviated DSS-induced colitis. *P<0.05 vs. saline + DSS group. CRF, corticotropin-releasing factor; CRF-R1, corticotropin-releasing factor receptor 1; DSS, dextran sulphate sodium; ip, intraperitoneal.