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. 2017 Oct 26;17(1):234–242. doi: 10.3892/mmr.2017.7909

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Effect of CRF-R1 on infiltration of macrophages in colon samples obtained from DSS-treated mice. (A) Compared with normal mice, a significant number of macrophages accumulated in the mucosa and submucosa of the colon on the seventh day of DSS treatment, which appeared as brown cytoplasmic staining. The ip injection of CP154526 significantly decreased the infiltration of macrophages in colon samples. (B) The ip injection of CRF slightly increased the number of macrophages in the colon samples. *P<0.05 vs. saline + DSS group. ^#P<0.05 vs. normal group. CRF, corticotropin-releasing factor; CRF-R1, corticotropin-releasing factor receptor 1; DSS, dextran sulphate sodium; ip, intraperitoneal; CD68, cluster of differentiation.