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Effect of CRF-R1 on NF-κB phosphorylation in colon samples from DSS-treated mice. (A) The ip injection of CRF increased the expression level of p-p65 NF-κB, and CP154526 decreased the expression level of p-p65 NF-κB in the colon samples compared with those from the saline + DSS group. (B) *P<0.05 vs. saline + DSS group. CRF, corticotropin-releasing factor; CRF-R1, corticotropin-releasing factor receptor 1; NF-κB, nuclear factor-κB; DSS, dextran sulphate sodium.
