Table I.
Effect of CRF-R1 on DAI of DSS-induced mice.
| Groups | Day 1 | Day 3 | Day 5 | Day 6 | Day 7 |
|---|---|---|---|---|---|
| Normal group | 0.000±0.000 | 0.042±0.118 | 0.083±0.154 | 0.042±0.118a | 0.083±0.153a |
| Saline + DSS group | 0.125±0.173 | 0.750±0.636b | 1.833±1.141 | 2.917±1.318 | 3.417±0.886 |
| CRF + DSS group | 0.167±0.252 | 0.916±0.463b | 2.082±0.635a | 3.500±0.535a | 3.917±0.155a |
| CP154526 + DSS group | 0.124±0.171 | 0.750±0.344b | 1.417±0.497a | 2.417±0.683a | 3.084±0.463a |
As the number of days the animals received DSS-containing water increased, the DAI score increased. CRF increased the DAI score and CP154526 decreased the DAI score compared with the saline + DSS group.
a
P<0.05 vs. the saline + DSS group
b
P<0.05 vs. normal group. CRF, corticotropin-releasing factor; CRF-R1, corticotropin-releasing factor receptor 1; DAI, disease activity index; DSS, dextran sulphate sodium.