Figure 1.

Gene and modular domain structure of CCN1/Cyr61. The CCN1/Cyr61 gene is transcribed into RNA and then translated into the protein. Each exon and its corresponding RNA and protein is depicted as a rectangle with a unique color. The module name of the protein is presented under the rectangle. The binding sites of integrin and HSPGs in the CCN1/Cyr61 protein are marked as dotted lines. CCN1/Cyr61, cysteine-rich angiogenic inducer 61; UTR, untranslated region; IGFBP, insulin-like growth factor binding protein; vWC, von Willebrand factor type C repeats; TSP-1, thrombospondin type 1; HSPG, heparan sulfate proteoglycans.