Figure 1.

The transport of cholesterol in Sertoli cells. Generally, ABCA1 and SR-BI, two important cholesterol transporters on the membrane, mediate the transport of cholesterol in Sertoli cells. Sertoli cells obtain a large amount of cholesterol from the uptake of HDL-cholesterol esters through SR-BI. In addition, ABCA1 mediates the efflux of surplus cholesterol in Sertoli cells, which maintains the homeostasis of cholesterol levels. ABCA1, ATP-binding cassette subfamily A member 1; SR-BI, scavenger receptor class B member I; HDL, high-density lipoprotein.