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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: Biometrics. 2016 Nov 14;73(2):571–581. doi: 10.1111/biom.12612

Table 4.

Summary results based on BMI (kg/m2) values after adjusting for covariates and population structure and after adjusting for covariates, population structure and genotypic mean effects for top 10 SNPs. The rank of p-values are based on the results from the PLRT test.

P-value Mean SD


rs# Chr Position Gene MAF PLRT Lepage ANOVA Levene Du LRT(PB) AA Aa aa AA Aa aa
Results based on BMI value adjusting for covariates and population structure
rs2219576 4 52912589 SGCB 0.472 0.000 0.097 0.004 0.001 0.000 0.000 −0.30 0.33 −0.37 4.04 5.11 4.10
rs4898829 14 54602456 ATP5C1P1 0.344 0.000 0.018 0.423 0.009 0.007 0.005 0.05 0.04 −0.36 4.18 5.03 4.54
rs6049433 20 24127023 FLJ33581 0.439 0.000 0.000 0.000 0.028 0.003 0.015 0.23 −0.42 0.65 4.73 4.45 4.81
rs10968711 9 28676295 LINGO2 0.102 0.000 0.003 0.130 0.206 0.214 0.085 −0.10 0.39 0.72 4.67 4.48 2.42
rs12953383 18 41244911 IBTKP1 0.238 0.000 0.009 0.322 0.000 0.001 0.000 0.02 −0.12 0.49 4.82 4.03 5.80
rs10502817 18 41249142 IBTKP1 0.238 0.000 0.009 0.322 0.000 0.001 0.000 0.02 −0.12 0.49 4.82 4.03 5.80
rs1460242 8 106000000 RPL23P9 0.296 0.000 0.027 0.006 0.006 0.000 0.000 0.23 −0.06 −1.05 4.82 4.59 3.29
rs11646660 16 11648180 LITAF 0.111 0.000 0.002 0.014 0.004 0.010 0.010 −0.15 0.58 0.22 4.56 4.99 2.67
rs9504897 6 724502 EXOC2 0.083 0.000 0.003 0.158 0.017 0.137 0.005 −0.03 0.24 −1.20 4.62 4.69 1.26
rs17067163 8 3583092 CSMD1 0.074 0.000 0.257 0.026 0.004 0.002 0.000 0.10 −0.64 −0.35 4.78 3.50 4.33
Results based on BMI value adjusting for covariates, population structure and genotypic mean effect
rs756928 17 67877344 LINC01483 0.295 0.000 0.005 1.000 0.003 0.002 0.000 0.00 0.00 0.00 4.22 5.05 4.09
rs1519586 4 52846029 RPL37AP2 0.280 0.000 0.003 1.000 0.001 0.001 0.000 0.00 0.00 0.00 4.31 5.12 3.98
rs9359331 6 63886188 LOC442225 0.444 0.000 0.001 1.000 0.001 0.005 0.000 0.00 0.00 0.00 4.33 5.04 4.01
rs11745703 5 38755640 OSMR-AS1 0.416 0.000 0.006 1.000 0.004 0.009 0.000 0.00 0.00 0.00 4.03 4.92 4.83
rs7987211 13 42966734 FABP3P2 0.054 0.000 0.007 1.000 0.002 0.007 0.000 0.00 0.00 0.00 4.68 3.76 9.60
rs8177429 5 150403098 GPX3 0.080 0.000 0.002 1.000 0.003 0.020 0.000 0.00 0.00 0.00 4.74 3.73 6.53
rs768731 10 106834450 SORCS3 0.314 0.000 0.088 1.000 0.008 0.025 0.000 0.00 0.00 0.00 4.66 4.79 3.51
rs6491611 13 102089668 ITGBL1 0.119 0.000 0.004 1.000 0.006 0.017 0.000 0.00 0.00 0.00 4.84 4.03 2.92
rs26899 5 80360612 RASGRF2 0.252 0.000 0.007 1.000 0.004 0.045 0.000 0.00 0.00 0.00 4.67 4.75 3.25
rs6930903 6 28981244 ZNF311 0.264 0.000 0.004 1.000 0.004 0.005 0.000 0.00 0.00 0.00 4.38 5.06 3.69