Percent CST injury in two representative patients. Lesions are denoted in blue, the CST in red, and CST injury by the lesion in purple. [A] Severe CST injury: Two views of Patient 1, who had lesion volume of 7.0 cc and 93.7% CST injury. [B] Mild CST injury: Two views of Patient 2, who had lesion volume of 10.3 cc but only 18.7% CST injury. Despite similar lesion volumes, Patient 1 sustained greater percent injury to CST and had lower treatment-related gains in arm Fugl-Meyer score (1.5 points) as compared to Patient 2 (7.5 points).