Table 3.
The Diagnostic Performance of the 12-Gene Model for Lymph Node Metastasisa
| Sensitivity (90% CI) |
Specificity (90% CI) |
PPV (90% CI) |
NPV (90% CI) |
|
|---|---|---|---|---|
| Training set (n = 110) | 100% (74%–100%) | 42% (34%–51%) | 21% (14%–31%) | 100% (89%–100%) |
| Evaluation set (n = 112) | 100% (74%–100%) | 42% (34%–51%) | 21% (13%–31%) | 100% (89%–100%) |
| Validation set (n = 108) | 100% (74%–100%) | 41% (32%–50%) | 21% (14%–31%) | 100% (88%–100%) |
Abbreviations: CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.
a
On the basis of clinical consensus, we predetermined a cut-off probability of 0.04.