Table 1.

Baseline Characteristics by Trajectory

Characteristics	RAP (n=66)	CCI (n=71)	Early death (n=8)	p-value†	p-value‡
Male, n (%)	31 (47)	47 (66.2)	4 (50)	0.07	0.03
Age in years, mean (SD)	57.6 (13.3)	62.6 (14.7)	69.3 (10.5)	0.004	0.006
Age ≥65 years, n (%)	17 (25.8)	36 (50.7)	6 (75)	0.001	0.003
BMI, median (25th, 75th)	27.9 (24.2, 34.3)	28.8 (24.2, 34.8)	25.1 (20.9, 42.2)	0.96	0.97
Number of comorbidities*, n (%)				0.4	0.22
0	19 (28.8)	22 (31)	1 (12.5)
1	20 (30.3)	16 (22.5)	2 (25)
2	10 (15.2)	20 (28.2)	3 (37.5)
≥3	17 (25.8)	13 (18.3)	2 (25)
Charlson comorbidity index score, mean (SD)	3.6 (2.6)	4.5 (3)	5 (1.9)	0.06	0.04
APACHE II score, mean (SD)	18.4 (7.8)	23.6 (7.9)	24.9 (7.5)	0.001	<0.001
Delayed sepsis onset**, n (%)	10 (15.15)	44 (62)	1 (12.5)	<0.001	<0.001
Inter-facility hospital transfer, n (%)	21 (31.8)	34 (47.9)	6 (75)	0.03	0.08
Sepsis severity, n (%)				<0.001	0.002
Sepsis	21 (31.8)	8 (11.3)	0 (0)
Severe sepsis	28 (42.4)	27 (50.7)	1 (12.5)
Septic shock	17 (25.8)	36 (38)	7 (87.5)
Sepsis diagnosis, n (%)				0.13	0.15
Intra-abdominal sepsis	24 (36.4)	33 (46.5)	7 (87.5)
Pneumonia	9 (13.6)	17 (23.9)	0
NSTI	15 (22.7)	8 (11.3)	0
UTI	8 (12.1)	3 (4.2)	0
Surgical site infection	4 (6.1)	4 (5.6)	0
Other	6 (9.1)	6 (8.5)	1 (12.5)
Sepsis source control procedure, n (%)	33 (50)	40 (56.3)	6 (75)	0.38	0.5

Definition of Abbreviations: BMI, body mass index; APACHE II, acute physiology and chronic health evaluation II; NSTI, necrotizing soft tissue infection; UTI, urinary tract infection.

^*Comorbidities included those defined within the Charlson Comorbidity Index

^**Delayed sepsis onset, defined as sepsis occurring >2 days after hospital admission due to post-surgical or post-trauma infection

^†p-value comparing three groups overall

^‡p-value comparing two groups (RAP vs CCI)