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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Semin Cell Dev Biol. 2017 Jul 23;76:179–190. doi: 10.1016/j.semcdb.2017.07.021

Figure 4. Respirasome biogenesis through the stepwise association of partially-assembled respiratory chain complexes and submodules.

Figure 4

This model [45] proposes the sequential and coordinated association of submodules and free subunits from CIII2 (green) and CIV (red) to a CI-scaffold (blue) that lacks the N catalytic module, which is incorporated at the latest assembly stage to ensure respirasome activation in the presence of all the necessary structural components. The assembly pathways of individual CIII2 and CIV are depicted according to stablished models [72,108], and SC III2+IV1 is formed independently of the respirasomes [98]. Supercomplex assembly factors COX7A2L and HIGD2A are marked in green/red.