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. 2018 Jan 19;8:976. doi: 10.3389/fphar.2017.00976

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Copyright © 2018 Zhang, Wang, Zhu, Xu, Zhao, Zhao, Tang, Li, Zhou, Gao, Tian and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Carnosic acid significantly ameliorates BDL-induced liver fibrosis in rats. (A) Masson staining for collagen deposition in rat liver sections (x200). The hyperplasia of the lattice fibers and collagenous fibers has been marked with arrows. (B) Immunohistochemistry for α-SMA in rat livers (x200). (C) The protein expression of α-SMA and type 1 collagen in the liver was measured by western blot (n = 3); the results were normalized relative to the expression of GAPDH. The data are presented as the means ± SD. ^∗∗P < 0.01 versus the sham group; ^##P < 0.01 versus the BDL group.