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. 2018 Jan 19;8:976. doi: 10.3389/fphar.2017.00976

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Copyright © 2018 Zhang, Wang, Zhu, Xu, Zhao, Zhao, Tang, Li, Zhou, Gao, Tian and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Carnosic acid inhibits LX2 activation by inhibiting HMGB1. LX2 cells were randomly divided into three groups: pcDNA3.1-control, pcDNA3.1-control + CA (20 μM), and pcDNA3.1-HMGB1 + CA (20 μM). After transfection with the plasmid for 24 h, the cells were treated with CA for 12 h, and protein was then extracted. The protein expression levels of α-SMA, HMGB1, TLR4 and nuclear NF-κB p65 in LX2 cells were detected by western blot (n = 3). The data are presented as the means ± SD. ^∗∗P < 0.01 versus the control group; ^#P < 0.05 versus the CA group; ^##P < 0.01 versus the CA group.