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. 2018 Jan 19;8:976. doi: 10.3389/fphar.2017.00976

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Copyright © 2018 Zhang, Wang, Zhu, Xu, Zhao, Zhao, Tang, Li, Zhou, Gao, Tian and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulatory effect of miR-29b-3p on HMGB1 expression. (A) The levels of miR-300 and miR-29b-3p in the liver of rats were assayed by qPCR (n = 6). The data are presented as the means ± SD. ^∗∗P < 0.01 versus the sham group; ^#P < 0.05 versus the BDL group; ^##P < 0.01 versus the BDL group. (B,C) LX2 cells were randomly divided into four groups: mimic-miR-29b-3p-control, mimic-miR-29b-3p, mimic-miR-300-control, and mimic-miR-300. The cells were exposed to various treatments for 24 h before extraction of total protein. The HMGB1 protein level in LX2 cells was detected by western blotting (n = 3). The data are presented as the means ± SD. ^∗∗P < 0.01 versus the control group.