Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 19;8:976. doi: 10.3389/fphar.2017.00976

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Zhang, Wang, Zhu, Xu, Zhao, Zhao, Tang, Li, Zhou, Gao, Tian and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Carnosic acid-mediated protection against BDL-induced liver fibrosis might involve the down-regulation of MMP9, TGF-β1, and its receptor. The expression levels of MMP9 mRNA and MMP9, TGF-β1 and TGF-β R1 protein in livers and LX2 cells were detected. (A) The protein levels of MMP9, TGF-β1 and TGF-β R1 in the liver were analyzed by western blot (n = 3). (B) The mRNA levels of MMP9 in the liver were analyzed by qPCR (n = 6). The data are presented as the means ± SD. ^∗∗P < 0.01 versus the sham group; ^#P < 0.05 versus the BDL group; ^##P < 0.01 versus the BDL group. LX2 cells were randomly divided into two groups: control group and CA (20 μM) group. The cells were treated with 20 μM CA for 12 h before the extraction of total protein or RNA. (C) The protein levels of MMP9, TGF-β1 and TGF-β R1 in LX2 cells were analyzed by western blot (n = 3). (D) The mRNA levels of MMP9 in LX2 cells were analyzed by qPCR (n = 3). The data are presented as the means ± SD. ^∗∗P < 0.01 versus the control group; ^∗P < 0.05 versus the control group.