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. 2018 Jan 19;9:6. doi: 10.3389/fphys.2018.00006

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Copyright © 2018 Yan, Liu, Wang, Li, Chen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acute SCI caused upregulation of AQP4 and NKCC1 expression. The mRNA levels of AQP4 (A) and NKCC1 (B) at different time points after SCI were analyzed by quantitative PCR. (C) AQP4 and NKCC1 protein levels at different time points after SCI were assessed by western blot. (D) Quantitative analysis of the changes of AQP4 and NKCC1 protein in spinal cord after SCI. N = 7. ^*p < 0.05 compared to control (0 h), ^#p < 0.05 compared to 6 h, ˆp < 0.05 compared to 24 h, ⁺p < 0.05 compared to 72 h.