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. 2018 Jan 19;8:1998. doi: 10.3389/fimmu.2017.01998

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Copyright © 2018 Menon, Kapulu, Taylor, Jewell, Li, Hill, Long, Miura and Biswas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunogenicity of chimpanzee adenovirus 63 (ChAd63)–modified Vaccinia Ankara (MVA) vaccination with mixed or co-administered antigens in mice. Day 70 antigen-specific IgG responses in mice after immunization with ChAd63-MVA expressing Pfs25, Pfs230, Pfs28, and GFP [vector control (VC)] antigens. Constructs were administered by premixing antigens prior to vaccination (mixed) or co-administering (Co-ad) by vaccinating each antigen separately. The figure shows the total IgG response against Pfs25 [(A) two independent immunization experiments were conducted of experiment 1: n = 8/group (open symbols) and experiment 2: n = 5/group (closed symbols)], Pfs230C (B), and Pfs28 (C). Response was measured by standardized ELISA (A,B) and expressed in antibody units. Anti-Pfs28 antibody levels were measured by endpoint ELISA (C) and expressed as Pfs28 endpoint titer. Median and individual data points are shown. Kruskal–Wallis tests showed p = 0.0682 (A), p = 0.2445 (B), and p = 0.0304 (C), respectively. Dunn’s multiple comparison posttests showed no significant difference.