Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Multistep model of circulating blood cell adhesion and migration along the vascular endothelium. Cells make adhesive contacts onto the inflamed endothelial surface through engagement of their sialofucosylated glycan determinants to vascular E-selectin (Step 1—tethering and rolling). Subsequent engagement of chemokine receptors leads to integrin activation (Step 2) and firm adhesion of leukocytes to endothelium (Step 3), allowing their transmigration (Step 4).
