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Schematic representation of biosynthesis of the E-selectin ligand determinants. The α(2,3)-sialyltransferases, ST3Gal-III, -IV, and -VI, terminate the elongation of both O- and N-glycans by creating sialylated type 2 lactosamine chains. These can be further fucosylated by the action of the specific fucosyltransferases, yielding different Lewis-related structures that display E-selectin binding activity.
