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. 2018 Jan 23;8:1420. doi: 10.1038/s41598-018-19300-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cancer cell-specific killing effect of the oncolytic adenoviruses. (a) Glioblastoma cells (U87MG and U251N) and (b) normal cells (BJ and SVG-P12) were infected with Rb7Δ19, H5CmTERT-Ad, or H5CmTERT-Ad/TRAIL at the indicated MOI and incubated under normoxic or hypoxic conditions. At 48 h after the infection, cell viability was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Each cell line was tested at least three times, and data are shown as mean ± SD of triplicate experiments; *P < 0.05, **P < 0.01, ***P < 0.001.