Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 19;8:3. doi: 10.3389/fcimb.2018.00003

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Oliva, Sahr and Buchrieser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model the stringent response network governing L. pneumophila differentiation. Amino acid and fatty acid starvation triggers RelA and SpoT to produce the alarmone (p)ppGpp. Its accumulation induces the activation of the stress sigma factor RpoS, the LetA/LetS TCS and consequently an increased transcription of the RsmZ, RsmX, and RsmY sRNAs. The three sRNAs act as “sponge,” sequestering CsrA and leading thereby to the activation of the infectious traits and to changes in the metabolism. The dashed arrows indicate suggested but not yet confirmed direct interactions.