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Dynamic protein S-palmitoylation. Palmitate is transferred to the thiol group of cysteine from palmitoyl-CoA by integral membrane zDHHC-family palmitoyl acyltransferases. Upon S-palmitoylation cytosolic proteins gain a hydrophobic moiety allowing their anchoring in the membrane. Proteins are depalmitoylated by acylthioesterases [acyl-protein thioesterase (APT) 1/APT2 and ABHD17] and translocate to the cytosol.
