Table 2.
B and T cell phenotypic characteristics [median (Q1, Q3) N] by HIV exposure.
| Assay | Median (Q1, Q3); N |
p-Values |
||||
|---|---|---|---|---|---|---|
| PHEU | PHIV | HUU | PHIV:PHEU | PHIV:HUU | PHEU:HUU | |
| CD4+: %CD38+ HLADR+ (activated T cells) | 7.1 (5.0, 10.8); 38 | 7.9 (4.3, 10.8); 39 | 27.5 (22.9, 39.8); 4 | 0.87 | 0.002 | 0.002 |
| CD4+: %IL17+ (mucosal inflammatory T cells) | 2.8 (1.3, 5.9); 40 | 3.2 (1.6, 6.8); 42 | 0.7 (0.4, 1.2); 4 | 0.71 | 0.013 | 0.014 |
| CD4+: %CD25+ FOXP3+ (regulatory T cells) | 0.1 (0.0, 0.2); 38 | 0.1 (0.0, 0.2); 39 | 0.3 (0.2, 0.4); 4 | 0.43 | 0.11 | 0.06 |
| CD4+: %IL10+ (regulatory T cells) | 2.3 (1.0, 3.4); 40 | 2.0 (1.3, 3.2); 42 | 5.8 (5.2, 7.5); 4 | 0.71 | 0.004 | 0.014 |
| CD4+: %TGFβ+ (regulatory T cells) | 2.8 (1.6, 4.3); 40 | 2.5 (1.5, 5.2); 42 | 4.5 (2.6, 5.6); 4 | 0.85 | 0.51 | 0.37 |
| CD8+: %CD38+ HLADR+ (activated T cells) | 14.4 (10.8, 21.6); 37 | 13.1 (10.4, 19.3); 38 | 23.4 (21.9, 39.1); 4 | 0.62 | 0.030 | 0.043 |
| CD8+: %IL17+ (mucosal inflammatory T cells) | 4.8 (2.4, 11.1); 41 | 4.7 (2.2, 10.3); 43 | 3.3 (1.9, 5.1); 4 | 0.92 | 0.35 | 0.34 |
| CD8+: %CD25+ FOXP3+ (regulatory T cells) | 0.3 (0.1, 0.5); 37 | 0.2 (0.1, 0.4); 38 | 0.4 (0.3, 0.5); 4 | 0.21 | 0.16 | 0.46 |
| CD8+: %IL10+ (regulatory T cells) | 2.3 (1.5, 6.0); 41 | 1.8 (1.3, 5.6); 43 | 3.1 (2.0, 4.7); 4 | 0.66 | 0.61 | 0.81 |
| CD8+: %TGFβ+ (regulatory T cells) | 3.2 (2.0, 5.6); 41 | 3.8 (1.7, 8.2); 43 | 5.5 (2.9, 7.4); 4 | 0.73 | 0.70 | 0.40 |
| CD19+: %CD10+ (immature B cells) | 11.3 (6.6, 25.2); 41 | 11.9 (6.1, 23.9); 42 | 12.1 (10.1, 15.0); 4 | 0.89 | 0.82 | 0.97 |
| CD19+: %C10− CD21+ CD27− (naive B cells) | 25.5 (19.0, 33.3); 41 | 21.4 (11.5, 27.4); 42 | 51.4 (45.5, 60.2); 4 | 0.040 | 0.004 | 0.006 |
| CD19+: %C10− CD21+ CD27+ (memory B cells) | 32.4 (14.5, 52.5); 41 | 35.0 (17.3, 49.2); 42 | 15.4 (10.8, 18.2); 4 | 0.82 | 0.07 | 0.10 |
| CD19+: %C10− CD21− CD27− (exhausted B cells) | 31.6 (21.4, 48.9); 41 | 27.4 (20.7, 51.8); 42 | 21.9 (20.8, 23.3); 4 | 0.95 | 0.14 | 0.15 |
| CD19+: %IL10+ (regulatory B cells) | 2.5 (1.5, 3.3); 41 | 2.6 (1.7, 3.6); 39 | 5.3 (4.0, 7.5); 4 | 0.89 | 0.013 | 0.013 |
| CD19+: %TGFβ+ (active B cells) | 4.2 (2.0, 14.8); 41 | 3.7 (1.5, 11.2); 39 | 10.0 (4.9, 13.9); 4 | 0.61 | 0.24 | 0.52 |
Analyses were performed in perinatally HIV-infected infants (PHIV) and perinatally HIV-exposed uninfected (PHEU) data obtained at study entry; HIV-uninfected unexposed (HUU) had only one data set available at 6 months of life. Comparisons with p-values < 0.05 are bolded.