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. 2018 Jan 23;8:1400. doi: 10.1038/s41598-018-19664-9

Figure 3.

Figure 3

Evaluation of Percentages of Cell Death in Primary Cultures of Rat Cortical Neurons Exposed to HDAC Inhibitors. Cell death (%) in primary cultures of rat cortical neurons was determined by measuring LDH release 24 h or 48 h after OGD. Cultures were incubated with (A) 1a, 3, 4 or 5 each at 1 μM; (B) 6, 7, 8 or 1a each at 1 μM; (C) 8 or 1a each at 1 μM; (D) 1b, 2a or 2b each at 1 μM, under the conditions noted in the section of Materials and Methods. Each value is the mean ± standard error mean of triplicate measurements. The asterisk denotes a significant difference (*p < 0.05) versus the control (0.1% DMSO).