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. 2018 Jan 23;8:1400. doi: 10.1038/s41598-018-19664-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose-Dependent Evaluation of Percentages of Cell Death in Primary Cultures of Rat Cortical Neurons Exposed to HDAC Inhibitors. Cell death (%) in primary cultures of rat cortical neurons was determined by measuring LDH release 48 h after OGD. Cultures were incubated with (A) 8 or 1a each at 0.1, 0.3, 1, 3 or 10 μM; (B) FK228 (at 0.1, 1 or 10 μM), MS-275 (at 0.3, 1, 10 μM), 1a (at 0.3 μM) and 8 (at 3 μM); (C) 9, 10, 11 (each at 1, 3 or 10 μM), 1a (at 0.3 μM) and 8 (at 3 μM), under the conditions noted in the section of Materials and Methods. Each value is the mean ± standard error mean of triplicate measurements. The asterisk denotes a significant difference (*p < 0.05) versus the control (0.1% DMSO).