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. 2018 Jan 23;8:1419. doi: 10.1038/s41598-018-19581-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) TEM image of MSC exosomes and analysis of exosome size by nanoparticle tracking analysis. (B) Total reads of the top 50 miRNAs are shown. All miRNAs were normalized to positive and negative controls. miRNA profiling was performed using the NanoString platform and analyzed with nSolver Software 3. (C) Correlation of biological replicates of miRNA read counts of MSC exosomes. The Pearson correlation coefficient is 0.93. (D) The top 23 miRNAs account for 79.1% of total miRNAs present in MSC exosomes.