Table 1.
A list of abbreviations and the functions of iron related proteins.
Abbreviation | Function | |
---|---|---|
Divalent metal transporter 1 | DMT1 | Cellular iron importer responsible for ferrous iron uptake |
Ferroportin1 | FPN1 | Cellular iron exporter responsible for ferrous iron release |
Ceruloplasmin | Cp | A ferroxidase mediating oxidization of Fe2+ to Fe3+ and promoting FPN1-mediated iron release |
Transferrin/transferrin receptor 1 | Tf/TfR1 | A major pathway for Fe3+ ions acquisition to cells by a receptor-mediated pathway |
Lactoferrin/lactoferrin receptor | Lf/LfR | Transfers Fe3+ ions to cells by a receptor-mediated pathway |
Ferritin | Ferritin | Intracellular iron-storage protein, keeping iron in a non-toxic form |
Hepcidin | Hepcidin | A circulating peptide that binds to FPN1, mediating degradation of FPN1 |