Table 1.

Determination of K_d values for de-coppering drugs. The efficiency of de-coppering drugs to demetallate Cu₁Cox17 and/or Cu₁₀MT (C₅₀) was in linear correlation with K_d values for Cu(I)-binding complexes (conditions: 20 mM ammonium acetate, pH 7.3, 25 °C).

Ligand	C50 (mM) for Cu1Cox17	Kd (M)
DTT	3.10 ± 0.26	5.01 × 10−16*
DETC	0.00528 ± 0.00032	8.53 × 10−19
PA	1.47 ± 0.33	2.38 × 10−16
TR	1.08 ± 0.13	1.74 × 10−16
BAL	0.00938 ± 0.00148	1.52 × 10−18
DMS	0.00314 ± 0.00041	5.07 × 10−19
TTM	<0.001	<1.6 × 10−19
DLA	0.498 ± 0.098	8.05 × 10−17
Ligand	C 50 (mM) for Cu 10 MT	K d (M)
DETC	0.772 ± 0.087	8.53 × 10−19
TTM	0.0211 ± 0.0014	2.32 × 10−20

*Taken from reference²⁰.