Table 2.

Analysis between MGMT hypermethylation and NSCLC different clinicopathological features.

Analysis	Studies N	Methylation N(+/−)	OR(95% CI)	Method	Heterogeneity		P value
					I 2 (%)	P value
NSCLC	20	476/2115	4.60 [3.46, 6.11]	Fixed	47	0.01	<0.00001
age	5	180/405	1.21 [0.83, 1.77]	Fixed	32	0.21	0.31
sex	13	491/976	0.83 [0.65, 1.06]	Fixed	42	0.05	0.14
smoking	12	533/873	1.29 [0.73, 2.28]	Random	72	<0.00001	0.39
pathological types	15	497/970	0.80 [0.63, 1.01]	Fixed	21	0.22	0.06
differentiation	4	115/238	2.02 [0.89, 4.55]	Random	51	0.11	0.09
clinical stage	14	491/953	0.77 [0.59, 0.99]	Random	50	0.02	0.04