Figure 2.

Extended VWT training strongly increased mouse VA. Mice were initially trained in the VWT to discriminate a vertical, low spatial frequency sine wave grating from isoluminant gray. Standard VA was determined after 18 ± 3 d (545 ± 88 trials) of VWT training; after a total of 66 ± 7 d (1987 ± 207 trials), long-term VA was determined. A, VA of an animal in cyc/deg plotted against total trials/training days of VWT-experience. B, Average VA-curve of the VWT/no-MD group (n = 5, mean ± SEM): individual curves were averaged starting from the test phase (time point 0). Gray vertical lines indicate the timepoints of VA and corresponding OPT threshold determination.