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. 2017 Nov 7;15(1):633–640. doi: 10.3892/etm.2017.5453

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Characteristics of miR-31 expression. (A) miR-31 expression in both ASO and normal arteries was determined by RT-qPCR (n=6). ***P<0.001 vs. normal group. (B) miR-31 expression in the three layers of the ASO artery wall was determined by RT-qPCR (n=6). ***P<0.001 vs. adventitia and ^###P<0.001 vs. intima. (C) H&E staining revealed artery structures. Co-staining of miR-31 (red) and SM-α-actin (green) in artery sections. The ISH and immunofluorescence results showed that miR-31 was primarily localized in the arterial media and neointima. (D) IOD value of miR-31 staining in artery sections showed that miR-31 staining was significantly increased in ASO sections (n=6) compared with that in normal sections (n=6). Magnification, ×200. ***P<0.001 vs. normal group. miR, microRNA; ASO, arteriosclerosis obliterans; RT-qPCR; H&E, hematoxylin and eosin; SM, smooth muscle; IOD, integrated optical density; DAPI, 4′,6-diamidino-2-phenylindole; ISH, in situ hybridization.