(a) WGM sensor. A glass microsphere is used as optical microcavity, to sense physical, chemical and biological entities. (b) Near total internal reflection of light results in an optical resonance (WGM, shown in red). The WGM couples to a nano-antenna where it excites plasmon resonance. Within the plasmonic hot spots, various nanoscale detection tasks are accomplished, such as protein and nucleic acid detection. [122] John Wiley & Sons. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.