Table 2.

Summary table of study characteristics

Characteristic						Frequency
Study Design	Randomized controlled trial Observational prospective cohort study Observational retrospective cohort study					3 7 3
Recruitment	Monocentric hospital-based Multicentral hospital-based Population-based					9 1 3
Comparison: intervention vs. general populationa	RP	EBRT	ADT	WW	AS
	X					2
		Xb				5
			X			1
				X		1
					X	1
Comparison: intervention vs. interventiona	RP	EBRT	ADT	WW	AS
	X	X			X	1
	X	Xd				1
	X	X				1
		X vs. Xc				1
		Xc	X			1
		X			X	1
		X		X		1
	X	X	X	X		1
	X	Xe		X		1
	X	Xf				1
Sample sizes (total population)	<100 101 – 200 780 1463 (after 5 years since randomization) respectively 1413 participants (6 years since randomization)					6 5 1 1
Years since diagnosis/ randomization	Long-term survivors (5-10 years after diagnosis) Very long-term survivors (10 + years after diagnosis)					10 3
Stage at diagnosis	Localized (T1/T2) PC Locally advanced (T3/T4 any N1/M1) PC Localized & locally advanced PC No information					3 2 7 1
Recurrent PC survivors	No information Excluded Included					10 1g 2
Progressive PC survivors	No information Excluded Included					5 3 5

^aSome studies had multiple comparisons

^b“Plus ADT and/or clinical progression”

^cPlus ADT

^dBrachytherapy

^eEBRT-C — Conventional radiation; EBRT-HD — High-dose mixed-beam radiation; EBRT-LD — Low-dose mixed-beam radiation; EBRT-MB — Standard protocol/mixed-beam radiation; EBRT-PB — Proton beam radiation

^fBrachytherapy

^gExcluded because they died