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. 2018 Jan 23;10:10. doi: 10.1186/s13148-018-0445-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Recurrent breakpoints and methylated CpG islands near interruption sites are shown in the above map of the HPV 16 genome. The arrows indicate the location and the attached boxes state the number of integrations identified in this study. The red boxes represent the nearby methylated CpG sites. The frequently interrupted regions of E1, E2/E4, L1, and L2 are represented by the blue boxes