Table IV (B).

Water involved in the interaction inside active site cleft of the enzyme-inhibitor complexes

Papain + E-64-C[32,33]		Distances in Å	Subsites of inhibitor
			in interaction
E-64-C (I):O18	232:OH2	2.98**	P1
E-64-C(II):O18	389:OH2	2.60**	P1
Caricain + E-64-C
E-64-C:O18	1468:OH2	3.47**	P1
E-64-C:O17	1520:OH2	3.46	P1
Chymopapain + E-64-C
E-64-C:O18	1464:OH2	2.69**	P1
E-64-C:O9	1317:OH2	3.20	P2
Actinidin + E-64-C
E-64-C:O18	1489:OH2	2.85**	P1
E-64-C:O9	1152:OH2	3.32	P2
E-64-C:O1	1454:OH2	3.21	P1
CalotropinDI + E-64-C
E-64-C:O18	445:OH2	3.09**	P1
E-64-C:O18	441:OH2	3.29**	P1
E-64-C:O17	455:OH2	3.21	P1
E-64-C:O9	1299:OH2	2.84	P2
E-64-C:O5	1406:OH2	3.41	P1
1299:OH2	1406:OH2	3.16
Papain + E-64[19]
E-64:O18	217:OH2	2.67**	P1
E-64:N17	216:OH2	2.45*	P3
Actinidin + E-64[20]
E-64:O18	582H:OH2	2.81**	P1
E-64:N17	257H:OH2	3.23*	P3
E-64:N15	54H:OH2	3.01
E-64:N17	54:OH2	3.57	P3
E-64:N15	54:OH2	3.01	P3
Caricain + E-64[21]
E-64:O18	310H:O	2.98**	P1
Chymopapain + E-64
E-64:O18	302:OH2	3.21**	P1
E-64:O9	1357:OH2	2.85	P2
E-64:N18	1128:OH2	3.14	P3
CalotropinDI + E-64
E-64:O18	196:OH2	2.91**	P1
E-64:O17	196:OH2	3.39	P1
E-64:O9	1370:OH2	2.94	P2
E-64:N15	1310:OH2	3.43*	P3
E-64:N18	1625:OH2	3.25	P3
E-64:N18	1363:OH2	3.06	P3
E-64:N17	1310:OH2	3.22*	P3