Figure 5.

Effects of adding simulated I_K1 on AP parameters. (A) Adding I_K1 prolongs the APD₉₀ of action potentials recorded from Cellartis Cardiomyocytes (n = 4) compared to constant current injection. With increasing I_K1 conductance, the prolongation of the action potential becomes smaller, consistent with the role of I_K1 in the final repolarization of the cardiac action potential. (B) Upstroke velocity of the action potentials after addition of simulated I_K1 is high, as with constant current injections, and decreases slightly with increasing I_K1 conductance.