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. Author manuscript; available in PMC: 2018 Jul 19.
Published in final edited form as: J Am Chem Soc. 2017 Jul 7;139(28):9515–9518. doi: 10.1021/jacs.7b05680

Table 2.

Reaction Scope for Synthesis of 2-Pyrrolidinones

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a

Conditions A: 1. CuCl (20 mol %), PhCH3, 105 °C, 4 Å MS (reaction times 5–16 h, see Supporting Information for each reaction); 2. +DABCO (40 mol %) for 3–10 h.

b

Conditions B: 1. CuCl (15 mol %), L (17 mol %), PhCF3, 120 °C, 4 Å MS for 5 h; 2. +DABCO (40 mol %) for 3 h.

c

Conditions C: CuCN (20 mol %), L (22 mol %), PhCH3, 120 °C, 4 Å MS for 41 h.

d

Conditions D: 1. CuCl (20 mol %), L (22 mol %), PhCF3, 105 °C, 4 Å MS for 17 h; 2. +DABCO (34 mol %) for 3 h. Ligands were complexed with [Cu] for 2 h.