Table 1.
Correlation of LBH expression with patients’ clinicopathological features in HCC
| Variable | LBH protein
|
|||
|---|---|---|---|---|
| All cases, n | Low expression, n (%) | High expression, n (%) | P-valuea | |
| Age (years) | ||||
| <51b | 107 | 96 (89.7) | 11 (10.3) | |
| ≥51 | 119 | 110 (92.5) | 9 (7.5) | |
| Gender | 0.115 | |||
| Male | 203 | 183 (90.1) | 20 (9.9) | |
| Female | 23 | 23 (100) | 0 (0) | |
| HbsAg | 0.156 | |||
| Positive | 207 | 187 (90.3) | 20 (9.7) | |
| Negative | 19 | 19 (100) | 0 (0) | |
| AFP (ng/mL) | 0.061 | |||
| <81c | 112 | 106 (94.6) | 6 (5.4) | |
| ≥81 | 112 | 98 (87.5) | 14 (12.5) | |
| Liver cirrhosis | 0.301 | |||
| No | 90 | 80 (88.9) | 10 (11.1) | |
| Yes | 127 | 118 (92.9) | 9 (7.1) | |
| Tumor size (cm) | 0.200 | |||
| <5.5d | 109 | 102 (93.6) | 7 (6.4) | |
| ≥5.5 | 115 | 102 (88.7) | 13 (11.3) | |
| AST/ALT | 0.042* | |||
| <1.4e | 115 | 109 (94.8) | 6 (5.2) | |
| ≥1.4 | 111 | 97 (87.4) | 14 (12.6) | |
| Relapse | 0.272 | |||
| No | 138 | 131 (94.9) | 7 (5.1) | |
| Yes | 66 | 60 (90.9) | 6 (9.1) | |
| Clinical stage | 0.027* | |||
| I–II | 179 | 167 (93.3) | 12 (6.7) | |
| III–IV | 47 | 39 (83.0) | 8 (17.0) | |
Notes:
a
Chi-square test.
b
Mean age.
c–e
Mean.
*
P<0.05.
Abbreviations: LBH, limb-bud and heart; HbsAg, hepatitis B surface antigen; HCC, hepatocellular carcinoma; AFP, alpha-fetoprotein; AST, aminotransferase; ALT, alanine aminotransferase.