Table 4.
Characteristics of the patients according to severity of COPD (GOLD stage)
| Parameters | GOLD stages of COPD | p | |||
|---|---|---|---|---|---|
|
| |||||
| Stage 1, n=2 | Stage 2, n=14 | Stage 3, n=11 | Stage 4, n=7 | ||
| Organisms, n (%) 0.069* | |||||
| S. aureus | 1 (50) | 4 (28.6) | 2 (18.2) | 1 (14.3) | 0.049† |
| S. pneumoniae | 0 | 2 (14.36) | 0 | 0 | 0.107‡ |
| Acinetobacter spp. | 1 (50) | 0 | 0 | 0 | 0.484|| |
| P. aeruginosa | 0 | 4 (28.6) | 5 (45.5) | 4 (57.12) | 0.494¶ |
| K. pneumoniae | 0 | 4 (28.6) | 4 (36.4) | 2 (28.6) | 0.890§ |
| Age, mean±SD | 60±12.73 | 61±9.96 | 65.3±8.78 | 57.1±6.82 | NS |
| BMI, mean±SD | 18.7±0.16 | 19.9±3.02 | 20±2.24 | 18.5±2.72 | NS |
| mMRC dyspnea score, mean±SD | 2.5±0.71 | 3.3±0.61 | 3.5±0.52 | 2.6±0.53 | NS |
| Exacerbations-per year, mean±SD | 2±0.00 | 1.9±1.44 | 2.5±1.21 | 2.6±0.98 | NS |
| Current smokers, n (%) | 2 (100) | 5 (35.7) | 2 (18.2) | 6 (85.7) | 0.021† 0.031¶ 0.005§ |
| PaO2, mmHg, mean±SD | 79.8±14.71 | 71.9±11.01 | 65.1±6.45 | 63.5±14.89 | NS |
| PaCO2, mmHg, mean±SD | 41.8±5.02 | 40.1±6.17 | 45.4±7.86 | 45.8±7.91 | NS |
| pH, mean ± SD | 7.4±0.01 | 7.4±0.04 | 7.4±0.1 | 7.4±0.07 | NS |
| Systemic steroid use, n (%) | 0 | 2 (14.3) | 2 (18.2) | 5 (71.7) | 0.009¶ 0.024§ |
| Inhaled steroid use, n (%) | 1 (50) | 8 (57.1) | 10 (90.9) | 6 (85.7) | NS |
BMI: Body Mass Index; mMRC: modified medical research council; NS: not significant; COPD: chronic obstructive pulmonary disease; GOLD: Global initiative for Lung Disease; SD: standard deviation
Data are given either in mean±SD or number (%)
*
GOLD stage 1 vs stage 2
†
GOLD stage 1 vs stage 3
‡
GOLD stage 1 vs stage 4
||
GOLD stage 2 vs stage 3
¶
GOLD stage 2 vs stage 4
§
GOLD stage 3 vs stage 4