Table 1.

Notable medicinal plants used in controlling menopause syndrome

References	Type of study	Mechanisms	Effects	Common name/Scientific name
16, 38	Clinical Trial	Bind to GABA complex/benzodiazepine Receptors in the brain, anti-perspiration feature, phytoestrogens	Treatment of flashes, sweats reduction, positive effects on the nervous system including improved memory	Sage herb/Saliva Officinalis
17, 39	Clinical Trial, Animal Study	Lemon balm aroma affects the nervous system	Treatment of sleep disorders, nervousness, gastrointestinal problems in menopause	Lemon balm/Melissa Officinalis
18,19,40	Clinical Trial, Clinical Trial, Cell Study	Increase of GABA in the synaptic cleft	Treatment of hot flashes in menopause	Valerian/Valerian Officinalis
21		No permanent effect on estrogen receptors	Treatment of menopause symptoms such as night sweat, hot flash, insomnia, irritability, palpitations and headache	Cimicifugaracemose/Black Cohosh
22,23	Clinical Trial-A systematic review	Inhibit the excess activity of testosterone	Treatment of vasomotor symptoms in menopause	Fenugreek/Trigonella Foenum
24	Clinical Trial	Visceral body fat reduction	Treatment of metabolic syndrome in menopause	The Black Seeds/Nigella sativa
25, 42	Clinical Trial, Randomized Trial	Stimulate the expression of genes related to progesterone receptors as well as its ability to eliminate defects in the synthesis of progesterone in luteal phase	Treatment of hot flashes	Hayfork/Vitex Agnuscastus
26, 42	Clinical Trial, Clinical Trial	Retard excessive production of testosterone	Treatment of menopausal symptoms and vaginal atrophy	Fennel/FoeniculumVulgare
27	Clinical Trial	Antioxidant activities, contains prostaglandin E1	Treatment of vasomotor symptoms	Oenotherabiennis/Evening Prim Rose
28	Clinical Trial	Antioxidant and vasodilator activities	Treatment of attention disorders, memory impairment in postmenopausal women	Ginkgo/Ginkgo Biloba
29	Clinical Trial	Estrogenic effects	Treatment of hot flashes	Alfalfa/Medicago Sativa
30	a randomized pilot trial,	Benzodiazepine receptor activation	Treatment of hot flashes	Hypericum (Hvfaryqvn)/Hypericume Perforatum
31	a randomized pilot trial	Estrogenic effects	Treatment of sleep disorders, fatigue, menopausal symptoms	Ginseng/Panax Ginseng
32	Clinical Trial	Estrogenic effects	Treatment of hot flashes	Anise/Pinpinella Aanisune
33	Clinical Trial	Estrogenic effects	Treatment of hot flashes	Glycyrrhiza Glabra/Licoric
34, 44	Clinical Trial, Animal Study	Activation of GABAA receptor	Treatment of menopausal symptoms and hot flashes and neurological disorders	Passion fruit/Passiflora Incarnata
35	Clinical Trial	Inhibit angiogenesis and provide protection agonist oxidative damage, anti-oxidant, estrogenic effect	Ability to reduce menopausal symptoms and support the maintenance of bone density and protect the cardiovascular and immune system	Red clover/Trifolium Pretense
36	Clinical Trial	Estrogenic effects	Ability to reduce menopausal symptoms, support the maintenance of bone density, protects the immune system	Soya/Glycine soja