Table 1.
Selected characteristics of the study population, imputed data
| Characteristics | Group | Cases (n = 2363) | Controls (n = 2198) | p-valuea |
|---|---|---|---|---|
| Sex | Female | 960 (40.6) | 860 (39.1) | 0.3013 |
| Male | 1403 (59.4) | 1338 (60.9) | ||
| Age (years) | <50 | 115 (4.9) | 70 (3.2) | 0.0257 |
| 50–59 | 343 (14.5) | 302 (13.7) | ||
| 60–69 | 769 (32.5) | 698 (31.8) | ||
| 70–79 | 770 (32.6) | 767 (34.9) | ||
| ≥80 | 366 (15.5) | 361 (16.4) | ||
| Personal history of colonoscopy | 521 (22.1) | 1208 (55.0) | <0.0001 | |
| FH | No FH | 1833 (77.6) | 1825 (83.0) | <0.0001 |
| SDR onlyb | 214 (9.1) | 159 (7.2) | ||
| FDRc | 316 (13.4) | 214 (9.7) | ||
| GRSd | Very low | 134 (5.7) | 220 (10.0) | <0.0001 |
| Low | 175 (7.4) | 220 (10.0) | ||
| Low–medium | 383 (16.2) | 439 (20.0) | ||
| Medium | 431 (18.2) | 439 (20.0) | ||
| Medium–high | 548 (23.2) | 441 (20.0) | ||
| High | 300 (12.7) | 220 (10.0) | ||
| Very high | 392 (16.6) | 219 (10.0) | ||
| Cancer stage | I | 540 (22.8) | – | |
| II | 721 (30.5) | – | ||
| III | 750 (31.7) | – | ||
| IV | 352 (14.9) | – | ||
| Cancer locatione | Proximal colon | 765 (32.3) | – | |
| Distal colon | 798 (33.8) | – | ||
| Rectum | 800 (33.9) | – |
Notes: Values are expressed as n (%).
a
p-value for difference in distributions across categories.
b
FH in any SDR only.
c
FH in at least one FDR.
d
Classification of GRS: very low, ≤10th percentile; low, 10th–20th percentile; low–medium, 20th–40th percentile; medium, 40th–60th percentile; medium–high, 60th–80th percentile; high, 80th–90th percentile; very high, >90th percentile.
e
Cancers in more than one location were allocated to the most proximal location (n = 34). ‘–’ indicates not applicable.
Abbreviations: FDR, first-degree relative; FH, family history; GRS, genetic risk score; SDR, second-degree relative.