Table 4.
ORs with 95% CI for the risk of CRC according to GRS and having a FH of CRC
| GRSa | FH of CRC
|
||
|---|---|---|---|
| No | SDR only | FDR | |
| Very low | 1.00–Ref. | 1.56 (0.68–3.57) | 1.68 (0.76–3.71) |
| Low | 1.31 (0.92–1.86) | 2.69 (1.11–6.52) | 2.57 (1.30–5.08) |
| Low–medium | 1.50 (1.10–2.03) | 1.94 (1.05–3.59) | 2.59 (1.52–4.41) |
| Medium | 1.44 (1.06–1.96) | 2.57 (1.48–4.47) | 3.27 (1.99–5.37) |
| Medium–high | 2.10 (1.56–2.84) | 2.51 (1.46–4.33) | 3.95 (2.41–6.46) |
| High | 2.50 (1.78–3.50) | 3.38 (1.73–6.60) | 2.33 (1.23–4.43) |
| Very high | 2.80 (2.02–3.88) | 6.48 (2.93–14.31) | 6.14 (3.47–10.84) |
Notes: Model adjusted for sex, age, education, previous colonoscopy, smoking, HRT among women, BMI before diagnosis; missing values, n = 75.
a
Classification of GRS: very low, ≤10th percentile; low, 10th–20th percentile; low–medium, 20th–40th percentile; medium, 40th–60th percentile; medium–high, 60th–80th percentile; high, 80th–90th percentile; very high, >90th percentile.
Abbreviations: BMI, body mass index; CRC, colorectal cancer; FH, family history; FDR, first-degree relative; GRS, genetic risk score; HRT, hormone replacement therapy; OR, odds ratio; Ref., reference; SDR, second-degree relative.