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. Author manuscript; available in PMC: 2018 Jan 24.
Published in final edited form as: ACS Chem Neurosci. 2017 Feb 9;8(2):221–234. doi: 10.1021/acschemneuro.6b00393

Figure 2.

Figure 2

Comparison of concentrations measured at acute and chronic CFMs without optimization for dopamine release sites. In a study with acute CFMs (Owesson-White et al., ref 87), electrode placement was optimized for extracellular electrophysiological signals rather than dopamine release, resulting in recording locations without (top) and with (middle) phasic dopamine release. The concentration profile corresponds well with values from chronically implanted CFMs that were not optimized for recording location (bottom), indicating the lower concentrations measured with chronic CFM may be a result of recording site selection. Reprinted with permissions from ref 86. Copyright 2012 PNAS.