Table 4.

Differences in task-related activity and rate-correlated activity between senior control participants (n = 18) and participants with PD (n = 15)

PD vs CON	Coordinates
Activity clusters (functional anatomy)	x		y	z	T value	PFWEcorr
Imagery task-related (CON > PD)
Left PMd	−30		−8	48	5.55	0.042
Movement rate-correlated (CON > PD)
Left visual areas	−36		−92	4	5.68	0.005
Right visual areas	48	−52		−16	5.68	0.005
Left SMA	−10	−2		60	4.75	0.045
Right cerebellum	12	−56		−22	4.75	0.045
Left PMd	−46	18		56	4.47	0.039svc ‡
Left posterior striatum-globus pallidus	−24	−14		−2	4.10	0.039svc †
Imagery rate-correlated (CON > PD)
Left posterior striatum-globus pallidus	−28	−10		−4	4.29	0.049svc †
Calculation rate-correlated (CON > PD)
Left pre-PMd	−30	2		62	5.91	0.001
Left parietal cortex	−44	−44		36	4.77	0.024
Left pre-SMA	−6	14		60	4.21	0.046svc ‡
Left caudate head	−14	−4		20	4.29	0.002svc †
Left IFC	−50	12		30	3.7	0.022svc †

Nodes of the BTC circuits in the left hemisphere are shown in italic fonts. CON: controls; svc^‡: significant for small volume correction within rate-correlated areas for each task from the whole healthy participants group; svc^†: significant for small volume correction within anatomically defined cortical areas or diffusion-based classification of subcortical nuclei.